Methotrexate 2.5 mg Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

MTX

Indications/Uses

Produces regression in acute leukaemias, non-Hodgkin's lymphoma, soft tissue & osteogenic sarcomas, & solid tumors eg, breast, lung, head & neck, bladder, cervical, ovarian & testicular carcinomas. Patient w/ severe psoriasis who are unresponsive to other forms of treatment.

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Dosage/Direction for Use

Not to exceed 30 mg/m² as single dose for not >5 successive days w/ 2-wk rest period between treatments.

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Overdosage

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Administration

Should be taken on an empty stomach: May be taken w/ meals to reduce GI discomfort. Avoid taking w/ milk-rich products.

Contraindications

Serious anaemia, leucopenia or thrombocytopenia. Severe renal or hepatic impairment.

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Warnings

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Special Precautions

Alcoholics or w/ ulcerative GIT disorders. Monitor plasma conc & urinary excretion during high-dose regimens; CBC w/ platelet counts & liver function. Maintain adequate urine flow. Hepatic or renal impairment. Concurrent use of aminobenzoic acid, chloramphenicol, phenylbutazone, phenytoin, probenecid, salicylates, sulphonamides & tetracyclines; NSAIDs. May impair fertility. Not to be administered during pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Leucopenia, thrombocytopenia, anaemia, mouth ulceration, stomatitis, diarrhea. Bone marrow depression, megaloblastic anaemia. Hypogammaglobulinaemia. Liver & kidney damage. Osteoporosis, effects on skin & nails, pulmonary reactions including interstitial pneumonitis. Metabolic alterations; neurotoxic reactions; teratogenic effects.

Drug Interactions

Enhanced effects w/ aminobenzoic acid, chloramphenicol, phenylbutazone, phenytoin, probenecid, salicylates, sulfonamides & tetracyclines. Fatal toxicity w/ NSAIDs.

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Caution For Usage

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Storage

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Description

View Methotrexate 2.5 mg description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Cytotoxic Chemotherapy / Disease-Modifying Anti-Rheumatic Drugs (DMARDs)

ATC Classification

L04AX03 - methotrexate ; Belongs to the class of other immunosuppressants.

Thai FDA Category

Presentation/Packing

Form

Methotrexate 2.5 mg tab 2.5 mg

Packing/Price

10 × 10's

Methotrexate 2.5 mg

methotrexate

Manufacturer:

Remedica

Distributor:

Pharmadica